Human Target follows the action packed life of Christopher Chance (played by Mark Valley). While being a body guard of sorts, Christopher Chance is hired to help draw out the enemies of his current client. When Christopher Chance is hired he promptly puts himself into a new persona that allows him to become a part of his clients life and in doing such he becomes the human target for whoever is out to harm his client. With help from his friend and business partner Winston (played by Chi McBride), Christopher Chance is able to get the new clients to keep up his lifestyle of living a secret life that even the government don’t know about. But even he needs to have some extra help in some tight spots and that help comes from Guerrero (played by Jackie Earle Haley).