Sometimes even being one of the top doctors around is not enough to save a life. No one knows this better than the staff at Chelsea General Hospital as they deal with every sort of sickness coming through the doors. Their only way of dealing with their own mistakes and others is by depending on each other to get through the tough moments of their jobs and lives. With every deed done the team of medical professionals meet every Monday morning to discuss all that has happened under their watch at the hospital. Chief of surgery Dr. Harding Hooten (played by Alfred Molina) oversees his crew and the meetings that could end their career if he finds out they are the ones to blame for the mistakes that kill.